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8 things to do before your first GLP-1 injection

The most common reason patients drop GLP-1 medications in the first month is unprepared GI distress. A small amount of prep — stocking the pantry, calibrating expectations, scheduling the right week — substantially raises the odds of staying on the medication long enough to see results.

6 min read Reviewed by Dr. Jane Novak, MDPublished 2026-05-15
  1. 1

    Stock easy-on-the-stomach foods

    Greek yogurt, eggs, bone broth, plain rice, bananas, applesauce, ginger tea. Prep for nausea in the first 2-4 weeks.

  2. 2

    Buy a hydration tracking bottle

    GLP-1s blunt thirst signals. Aim for 0.5-0.7 oz/lb body weight daily. A marked bottle removes the guesswork.

  3. 3

    Get an electrolyte mix

    LMNT, Liquid I.V. Hydration Multiplier, or a homemade mix. Sodium + potassium prevents the "GLP-1 lightheadedness" common in weeks 4-12.

  4. 4

    Pre-fill your protein plan

    Aim for 0.7-1.0 g/lb body weight daily. Stock protein shakes, jerky, edamame for low-appetite days. Use the macros calculator.

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  5. 5

    Schedule injection day to avoid major events

    Side effects peak 24-72 hrs after the first few injections. Inject on a Friday if your weekends are quieter; avoid travel.

  6. 6

    Read the FDA prescribing information for your drug

    Wegovy, Zepbound, Ozempic, Mounjaro PIs are on accessdata.fda.gov. Especially: contraindications, warnings, and the titration schedule.

  7. 7

    Take a starting photo and measurements

    Scale fluctuates daily. Measurements and photos tell the actual story over 8-12 weeks.

  8. 8

    Save your provider's message-the-clinician contact

    You'll want quick access during week 1 nausea or to request a dose-pause. Top-rated providers respond within 4 hours.

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Next step

Take the GLP-1 quiz

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