Evidence-graded answer
Can I switch from Wegovy to Zepbound?
Yes, and many patients do — SURMOUNT-5 (NEJM 2025) showed tirzepatide produced 20% mean weight loss vs 14% for semaglutide. Switching is usually done with a 1-week washout, starting Zepbound at 2.5 mg regardless of prior Wegovy dose.
There is no fixed equivalence between semaglutide and tirzepatide doses because tirzepatide is a dual GLP-1/GIP agonist with different pharmacology. Starting at the lowest tirzepatide dose (2.5 mg) and titrating per label is the standard approach.
A washout is not strictly required, but 5-7 days off Wegovy reduces overlap-related GI side effects.
Insurance coverage often forces the choice. Many plans cover one but not the other; copay assistance differs.
Source: SURMOUNT-5 NEJM 2025, NEJM