Ozempic side effect
Ozempic Constipation: causes, relief, and when to call a doctor
Constipation is reported by 15–25% of patients on GLP-1s. Slowed gastric emptying plus reduced food intake means less bulk reaching the colon — so stools become harder and less frequent.
Reviewed by Jane Novak, MD, MPHLast reviewed 2026-06-22Source: FDA Wegovy Prescribing Information §6.1 ↗ (opens in a new tab)
In trial — Ozempic
6.5%
In trial — placebo
2.5%
Severity
mild
Source: SUSTAIN-6 (Marso et al., NEJM 2016)