Does magnesium help with GLP-1 constipation?

Magnesium citrate (200–400 mg in the evening) is the most-recommended OTC option and is well-tolerated with GLP-1 medications. Magnesium oxide is cheaper but less effective. Talk to your prescriber if you have kidney disease before starting.

How much fiber should I eat on a GLP-1?

25–35 g/day, ramped up gradually (sudden increases worsen bloating). Whole-food sources beat supplements: chia seeds, ground flaxseed, berries, oats, beans, leafy greens.

Zepbound side effect

Zepbound Constipation: causes, relief, and when to call a doctor

Constipation is reported by 15–25% of patients on GLP-1s. Slowed gastric emptying plus reduced food intake means less bulk reaching the colon — so stools become harder and less frequent.

Reviewed by Jane Novak, MD, MPHLast reviewed 2026-06-22Source: FDA Wegovy Prescribing Information §6.1 ↗

In trial — Zepbound

11.7%

In trial — placebo

3.4%

Severity

mild

Source: SURMOUNT-1 (Jastreboff et al., NEJM 2022)

Zepbound Constipation: causes, relief, and when to call a doctor

Why constipation happens on Zepbound

How to manage it at home

Frequently asked

Other Zepbound side effects

Zepbound nausea

Zepbound diarrhea

Zepbound vomiting

Zepbound fatigue