The short answer
Continue your SSRI. No dose change needed.
Generally safeNo known interaction
Why it matters
Different metabolic pathways. SSRIs metabolized via CYP2D6/3A4; GLP-1s are peptide drugs (semaglutide, tirzepatide) cleared without significant CYP involvement, or orally absorbed small molecule (orforglipron) with minimal CYP impact.
What to do
Continue current SSRI. Monitor for emerging GI side effects in the first 2 weeks, as both can affect appetite/nausea.
Ask your prescriber
“I take SSRIs. Is Foundayo (orforglipron) safe with it, and what should we monitor?”
How SSRIs and Foundayo (orforglipron) interact
Different metabolic pathways. SSRIs metabolized via CYP2D6/3A4; GLP-1s are peptide drugs (semaglutide, tirzepatide) cleared without significant CYP involvement, or orally absorbed small molecule (orforglipron) with minimal CYP impact.
What to do
Continue current SSRI. Monitor for emerging GI side effects in the first 2 weeks, as both can affect appetite/nausea.
Before you start Foundayo (orforglipron)
A licensed prescriber reviews your full medication and supplement list before prescribing a GLP-1. If you take SSRIs, mention it at your consultation.
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Same question, other GLP-1s
Other things people check with Foundayo (orforglipron)
Full SSRIs interaction profile
See SSRIs reviewed against every GLP-1 on one page: SSRIs + GLP-1 interactions
Sources
Educational information, not medical advice. Always confirm interactions with your prescriber or pharmacist.