The short answer
Check INR more frequently for the first 6-8 weeks on a GLP-1.
Use with cautionGenerally OK with monitoring
Why it matters
GLP-1 delays gastric emptying, which can alter warfarin absorption. Reported INR shifts in both directions; no single predictable change.
What to do
INR check at 1, 2, 4, and 8 weeks after starting any GLP-1. Adjust warfarin dose only after a confirmed sustained shift. Once on GLP-1 maintenance for 3 months, INR stabilizes for most patients.
Ask your prescriber
“I take Warfarin. Is Foundayo (orforglipron) safe with it, and what should we monitor?”
How Warfarin and Foundayo (orforglipron) interact
GLP-1 delays gastric emptying, which can alter warfarin absorption. Reported INR shifts in both directions; no single predictable change.
What to do
INR check at 1, 2, 4, and 8 weeks after starting any GLP-1. Adjust warfarin dose only after a confirmed sustained shift. Once on GLP-1 maintenance for 3 months, INR stabilizes for most patients.
Before you start Foundayo (orforglipron)
A licensed prescriber reviews your full medication and supplement list before prescribing a GLP-1. If you take Warfarin, mention it at your consultation.
Compare telehealth providersWe earn affiliate commissions from listed providers. Rankings are based on patient-reported outcomes, not commissions. See our editorial standards.
Same question, other GLP-1s
Other things people check with Foundayo (orforglipron)
Full Warfarin interaction profile
See Warfarin reviewed against every GLP-1 on one page: Warfarin + GLP-1 interactions
Sources
Educational information, not medical advice. Always confirm interactions with your prescriber or pharmacist.