Interaction reference

GLP-1 receptor agonists with NSAIDs

No pharmacokinetic interaction, but both can cause GI upset. Combined use amplifies dyspepsia and reflux risk.

Reasonable as-needed. Avoid daily NSAIDs in the first 8 weeks of a GLP-1 if possible.

Also known as: ibuprofen, naproxen, Advil, Motrin, Aleve

Per-GLP-1 breakdown

Wegovysemaglutide 2.4 mg
Minor
Mechanism: No PK interaction; additive GI irritation only.
What to do: OK as needed. If you need daily NSAIDs (e.g., for arthritis), prefer COX-2 selective (celecoxib) and add a PPI. Reassess after GLP-1 maintenance dose is reached and GI side effects have settled.
Zepboundtirzepatide
Minor
Mechanism: No PK interaction; additive GI irritation only.
What to do: OK as needed. If you need daily NSAIDs (e.g., for arthritis), prefer COX-2 selective (celecoxib) and add a PPI. Reassess after GLP-1 maintenance dose is reached and GI side effects have settled.
Ozempicsemaglutide
Minor
Mechanism: No PK interaction; additive GI irritation only.
What to do: OK as needed. If you need daily NSAIDs (e.g., for arthritis), prefer COX-2 selective (celecoxib) and add a PPI. Reassess after GLP-1 maintenance dose is reached and GI side effects have settled.
Mounjarotirzepatide
Minor
Mechanism: No PK interaction; additive GI irritation only.
What to do: OK as needed. If you need daily NSAIDs (e.g., for arthritis), prefer COX-2 selective (celecoxib) and add a PPI. Reassess after GLP-1 maintenance dose is reached and GI side effects have settled.
Foundayoorforglipron
Minor
Mechanism: No PK interaction; additive GI irritation only.
What to do: OK as needed. If you need daily NSAIDs (e.g., for arthritis), prefer COX-2 selective (celecoxib) and add a PPI. Reassess after GLP-1 maintenance dose is reached and GI side effects have settled.

Sources

NSAID coadministration with GLP-1 agonists — Lexicomp drug interaction database

See other interactions

Full interaction index