What are the most common side effects of Wegovy?

The most commonly reported side effects of Wegovy from trial data are nausea, diarrhea, vomiting, constipation, headache.

How long do Wegovy side effects last?

Most Wegovy side effects (especially gastrointestinal) are dose-related and typically subside within 2-4 weeks at each dose level. Side effects are most pronounced during titration.

Trial-sourced incidence data

Wegovy side effects

Wegovy (semaglutide) has 6 documented side effects from peer-reviewed Phase 3 trial data. Click any effect for a patient-facing deep dive with management guidance.

Nausea
moderate44.2% of trial patientsgastrointestinal
Diarrhea
moderate31.5% of trial patientsgastrointestinal
Vomiting
moderate24.8% of trial patientsgastrointestinal
Constipation
mild23.4% of trial patientsgastrointestinal

Incidence rates from peer-reviewed pivotal-trial publications and FDA prescribing information. Individual experience varies — discuss any new symptoms with your prescriber. Medically reviewed by Jane Novak, MD, MPH.