Switching providers as part of the switch?
Some telehealth providers handle multi-drug formularies (Wegovy + Zepbound + Foundayo). Others carry only one. If you are switching drugs, see which providers carry your new target.
See top providers →How to switch between GLP-1 medications safely
- 1Talk to your prescriber first. Never switch GLP-1s without medical input. They will evaluate your current dose, tolerance, and efficacy and confirm the equivalent dose of the new drug.
- 2Use the chart above to find the equivalent dose. The conversions come from comparative trial data (SURPASS-2, SURMOUNT-1, STEP-1). Confirm with your prescriber before filling the new prescription.
- 3Wait 7 days after your last dose. For weekly injectables, this aligns to your normal injection day. For daily oral, take the last dose, then wait a full week before starting the new drug.
- 4Monitor the first 2 weeks closely. New or worsened GI side effects (nausea, abdominal pain) should prompt a check-in. Your prescriber may step the dose down and re-titrate.
Frequently asked questions
- Is there a 1:1 conversion between semaglutide and tirzepatide?
- No exact 1:1 — different molecules. The clinically-equivalent doses are derived from comparative trial data (SURPASS, SURMOUNT, STEP series). Use the chart above for the closest match and confirm with your prescriber.
- How long should I wait between stopping one GLP-1 and starting another?
- Standard guidance: wait at least 7 days after your last weekly injection before starting a different GLP-1. This allows the previous drug to clear and reduces stacking-related GI side effects.
- Do I need to titrate again when switching drugs?
- Not always. If you were tolerating a high dose of the previous drug, your prescriber may start you at a clinically-equivalent dose of the new one without re-titrating from the bottom. If you had significant side effects, restarting at the lowest dose is safer.
- Can I switch from oral semaglutide (Rybelsus) to injectable Wegovy?
- Yes. Wait 7 days after your last Rybelsus tablet, then start Wegovy at the dose your prescriber matches to your prior efficacy/tolerability. Rybelsus 14 mg has rough equivalence to Wegovy 1.0 mg injection.
Educational only — not medical advice. Dose conversions are derived from published trial data and clinical practice references. Actual dose adjustments must be made by a licensed prescriber who can evaluate your medical history, tolerance, and current regimen.