Evidence-graded answer
Why do I have no appetite on Zepbound?
Tirzepatide activates two gut hormones (GIP + GLP-1) that signal fullness to the brain at supra-physiologic levels. It's not willpower; the drug is mimicking your body's satiety signals.
GLP-1 and GIP receptors in the brain's appetite-regulation centers (hypothalamus, nucleus accumbens) get activated more strongly than normal eating ever produces.
Patients commonly report disappearance of "food noise" (intrusive thoughts about food) in week 3-4 — this is a documented brain-level effect, not a placebo report.
Aim for high-protein, fiber-forward meals even when not hungry — adequate intake protects lean mass and supports the body's normal nutritional needs during weight loss.