Skip to main content
glpverdict
Editorial medical reviewFDA & peer-reviewed sourcesUpdated weeklyMedically reviewed content
HomeCompareMounjaro vs Ozempic

Medication comparison

Mounjaro vs Ozempic

Medically reviewed by Dr. Jane Novak, MD, MPH 8 min read Fact checked Editorial integrityUpdated Jun 5, 2026

Mounjaro and Ozempic are both prescription medications (GIP/GLP-1 dual receptor agonist vs GLP-1 receptor agonist) used for Type 2 diabetes and Type 2 diabetes (Ozempic). The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.

Find a provider for Mounjaro or Ozempic →

Affiliate disclosure: we earn commission on signups. Editorial ranking stays independent.

This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.

Top 3 providers prescribing Mounjaro or Ozempic

Affiliate links — we earn commission on conversions; editorial ranking is independent.

Drug A

Mounjaro

tirzepatide

GIP/GLP-1 dual receptor agonist

Eli Lilly

See full overview

Drug B

Ozempic

semaglutide

GLP-1 receptor agonist

Novo Nordisk

See full overview

Overview

PropertyMounjaroOzempic
Generic nametirzepatidesemaglutide
Drug classGIP/GLP-1 dual receptor agonistGLP-1 receptor agonist
ManufacturerEli LillyNovo Nordisk
Brand namesMounjaroOzempic, Wegovy, Rybelsus

Approved uses

PropertyMounjaroOzempic
Approved indicationsType 2 diabetesType 2 diabetes (Ozempic), Chronic weight management (Wegovy)

Dosing

PropertyMounjaroOzempic
Typical dosingTitrate to 15 mg (weekly SC injection)Titrate to 2.4 mg (weekly SC injection)

Side effects & warnings

PropertyMounjaroOzempic
Top side effectsNausea (29.6%), Diarrhea (23%), Vomiting (12.6%)Nausea (44.2%), Diarrhea (31.5%), Vomiting (24.8%)
Contraindications——
Boxed warningYesYes

Special populations

PropertyMounjaroOzempic
PregnancyC — Discontinue at least 1 month before a planned pregnancy.C — Discontinue at least 2 months before a planned pregnancy due to long half-life.

Storage

PropertyMounjaroOzempic
StorageRefrigerate before first use. After first use, room temperature up to 21 days.Refrigerate 36-46°F (2-8°C) before first use. After first use, may be stored at room temperature 59-86°F (15-30°C) for up to 56 days. Protect from light. Do not freeze.

Cost

PropertyMounjaroOzempic
Avg monthly cost$1023.04$997.58

FDA boxed warning

Mounjaro: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Ozempic: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Frequently asked

What is the difference between Mounjaro and Ozempic?

Mounjaro is tirzepatide (GIP/GLP-1 dual receptor agonist) and Ozempic is semaglutide (GLP-1 receptor agonist). They have different active ingredients and slightly different side-effect profiles.

Is Mounjaro or Ozempic more effective for weight loss?

Head-to-head trial data favors tirzepatide-based medications (Mounjaro, Zepbound) over semaglutide-based medications (Ozempic, Wegovy) in average percent weight loss. SURMOUNT-1 reported ~20.9% mean weight loss on tirzepatide 15 mg; STEP 1 reported ~14.9% on semaglutide 2.4 mg over comparable timelines.

Can I switch between Mounjaro and Ozempic?

Switching between GLP-1 medications requires re-titration when crossing active ingredients (semaglutide ↔ tirzepatide). Always coordinate with your prescriber before switching.

Other GLP-1 head-to-head comparisons

Compare Mounjaro or semaglutide against another GLP-1

More medication context

Tools and guides that pair with this comparison.

Affiliate disclosure: we earn commissions when readers sign up through our links. Editorial ranking is independent.