What is the difference between Mounjaro and Ozempic?

Mounjaro is tirzepatide (GIP/GLP-1 dual receptor agonist) and Ozempic is semaglutide (GLP-1 receptor agonist). They have different active ingredients and slightly different side-effect profiles.

Is Mounjaro or Ozempic more effective for weight loss?

Head-to-head trial data favors tirzepatide-based medications (Mounjaro, Zepbound) over semaglutide-based medications (Ozempic, Wegovy) in average percent weight loss. SURMOUNT-1 reported ~20.9% mean weight loss on tirzepatide 15 mg; STEP 1 reported ~14.9% on semaglutide 2.4 mg over comparable timelines.

Can I switch between Mounjaro and Ozempic?

Switching between GLP-1 medications requires re-titration when crossing active ingredients (semaglutide ↔ tirzepatide). Always coordinate with your prescriber before switching.

Mounjaro vs Ozempic — Side-by-Side GLP-1 Comparison (2026)

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Overview

Property	Mounjaro	Ozempic
Generic name	tirzepatide	semaglutide
Drug class	GIP/GLP-1 dual receptor agonist	GLP-1 receptor agonist
Manufacturer	Eli Lilly	Novo Nordisk
Brand names	Mounjaro	Ozempic, Wegovy, Rybelsus

Property	Mounjaro	Ozempic
Approved indications	Type 2 diabetes	Type 2 diabetes (Ozempic), Chronic weight management (Wegovy)

Property	Mounjaro	Ozempic
Typical dosing	Titrate to 15 mg (weekly SC injection)	Titrate to 2.4 mg (weekly SC injection)

Side effects & warnings

Property	Mounjaro	Ozempic
Top side effects	Nausea (29.6%), Diarrhea (23%), Vomiting (12.6%)	Nausea (44.2%), Diarrhea (31.5%), Vomiting (24.8%)
Contraindications	—	—
Boxed warning	Yes	Yes

Property	Mounjaro	Ozempic
Pregnancy	C — Discontinue at least 1 month before a planned pregnancy.	C — Discontinue at least 2 months before a planned pregnancy due to long half-life.

Storage

Property	Mounjaro	Ozempic
Storage	Refrigerate before first use. After first use, room temperature up to 21 days.	Refrigerate 36-46°F (2-8°C) before first use. After first use, may be stored at room temperature 59-86°F (15-30°C) for up to 56 days. Protect from light. Do not freeze.

Mounjaro vs Ozempic

Mounjaro

Ozempic

Overview

Approved uses

Dosing

Side effects & warnings

Special populations

Storage

Cost

Frequently asked

More medication context

Mounjaro full overview

Ozempic full overview

GLP-1 shortage tracker

Are you a candidate?

Prior auth letter generator

12-month price trends

Mounjaro vs Ozempic

Mounjaro

Ozempic

Overview

Approved uses

Dosing

Side effects & warnings

Special populations

Storage

Cost

Frequently asked

Compare Mounjaro or semaglutide against another GLP-1

More medication context

Mounjaro full overview

Ozempic full overview

GLP-1 shortage tracker

Are you a candidate?

Prior auth letter generator

12-month price trends