Medication comparison
Ozempic and Rybelsus are both prescription medications (GLP-1 receptor agonist vs GLP-1 receptor agonist (oral tablet)) used for Type 2 diabetes. The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.
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This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.
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| Property | Ozempic | Rybelsus |
|---|---|---|
| Generic name | semaglutide | semaglutide (oral) |
| Drug class | GLP-1 receptor agonist | GLP-1 receptor agonist (oral tablet) |
| Manufacturer | Novo Nordisk | Novo Nordisk |
| Brand names | Ozempic | Rybelsus |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Approved indications | Type 2 diabetes | Type 2 diabetes |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Typical dosing | Titrate to 2.0 mg (weekly SC injection) | — |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Top side effects | Nausea (20.3%), Vomiting (9.2%), Diarrhea (8.5%) | — |
| Contraindications | — | — |
| Boxed warning | Yes | No |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Pregnancy | C — Discontinue at least 2 months before a planned pregnancy. | — |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Storage | Refrigerate before first use. After first use, room temperature up to 56 days. Protect from light. | — |
| Property | Ozempic | Rybelsus |
|---|---|---|
| Avg monthly cost | $935.77 | $1029.00 |
FDA boxed warning
Ozempic: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Ozempic is semaglutide (GLP-1 receptor agonist) and Rybelsus is semaglutide (oral) (GLP-1 receptor agonist (oral tablet)). They have different active ingredients and slightly different side-effect profiles.
See each drug's clinical-trials section for the registrational outcome data (SURMOUNT for tirzepatide; STEP for semaglutide; SCALE for liraglutide). Average weight loss varies by trial duration, dose ceiling, and adherence.
Switching between GLP-1 medications requires re-titration when crossing active ingredients (semaglutide ↔ tirzepatide). Always coordinate with your prescriber before switching.
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