Skip to main content
glpverdict
Editorial medical reviewFDA & peer-reviewed sourcesUpdated weeklyMedically reviewed content
HomeCompareOzempic vs Mounjaro

Medication comparison

Ozempic vs Mounjaro

Medically reviewed by Dr. Jane Novak, MD, MPH 8 min read Fact checked Editorial integrityUpdated Jun 5, 2026

Ozempic and Mounjaro are both prescription medications (GLP-1 receptor agonist vs GIP/GLP-1 dual receptor agonist) used for Type 2 diabetes. The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.

Find a provider for Ozempic or Mounjaro →

Affiliate disclosure: we earn commission on signups. Editorial ranking stays independent.

This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.

Top 3 providers prescribing Ozempic or Mounjaro

Affiliate links — we earn commission on conversions; editorial ranking is independent.

Drug A

Ozempic

semaglutide

GLP-1 receptor agonist

Novo Nordisk

See full overview

Drug B

Mounjaro

tirzepatide

GIP/GLP-1 dual receptor agonist

Eli Lilly

See full overview

Overview

PropertyOzempicMounjaro
Generic namesemaglutidetirzepatide
Drug classGLP-1 receptor agonistGIP/GLP-1 dual receptor agonist
ManufacturerNovo NordiskEli Lilly
Brand namesOzempicMounjaro

Approved uses

PropertyOzempicMounjaro
Approved indicationsType 2 diabetesType 2 diabetes

Dosing

PropertyOzempicMounjaro
Typical dosingTitrate to 2.0 mg (weekly SC injection)Titrate to 15 mg (weekly SC injection)

Side effects & warnings

PropertyOzempicMounjaro
Top side effectsNausea (20.3%), Vomiting (9.2%), Diarrhea (8.5%)Nausea (29.6%), Diarrhea (23%), Vomiting (12.6%)
Contraindications——
Boxed warningYesYes

Special populations

PropertyOzempicMounjaro
PregnancyC — Discontinue at least 2 months before a planned pregnancy.C — Discontinue at least 1 month before a planned pregnancy.

Storage

PropertyOzempicMounjaro
StorageRefrigerate before first use. After first use, room temperature up to 56 days. Protect from light.Refrigerate before first use. After first use, room temperature up to 21 days.

Cost

PropertyOzempicMounjaro
Avg monthly cost$935.77$1023.04

FDA boxed warning

Ozempic: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Mounjaro: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Already on Ozempic and considering Mounjaro?

Type 2 diabetes patients switching from semaglutide to tirzepatide for stronger glycemic control.

Read the switching guide

Frequently asked

What is the difference between Ozempic and Mounjaro?

Ozempic is semaglutide (GLP-1 receptor agonist) and Mounjaro is tirzepatide (GIP/GLP-1 dual receptor agonist). They have different active ingredients and slightly different side-effect profiles.

Is Ozempic or Mounjaro more effective for weight loss?

Head-to-head trial data favors tirzepatide-based medications (Mounjaro, Zepbound) over semaglutide-based medications (Ozempic, Wegovy) in average percent weight loss. SURMOUNT-1 reported ~20.9% mean weight loss on tirzepatide 15 mg; STEP 1 reported ~14.9% on semaglutide 2.4 mg over comparable timelines.

Can I switch between Ozempic and Mounjaro?

Yes — see our directional switching guide at /switching/ozempic-to-mounjaro for FDA-label dose conversion and what to expect during the transition.

Other GLP-1 head-to-head comparisons

Compare Ozempic or Mounjaro against another GLP-1

More medication context

Tools and guides that pair with this comparison.

Affiliate disclosure: we earn commissions when readers sign up through our links. Editorial ranking is independent.