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Zepbound vs Mounjaro

Medically reviewed by Dr. Jane Novak, MD, MPH 8 min read Fact checked Editorial integrityUpdated Jun 5, 2026

Zepbound and Mounjaro are both GIP/GLP-1 dual receptor agonist medications used for Chronic weight management and Type 2 diabetes. The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.

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This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.

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Drug A

Zepbound

tirzepatide

GIP/GLP-1 dual receptor agonist

Eli Lilly

See full overview

Drug B

Mounjaro

tirzepatide

GIP/GLP-1 dual receptor agonist

Eli Lilly

See full overview

Overview

PropertyZepboundMounjaro
Generic nametirzepatidetirzepatide
Drug classGIP/GLP-1 dual receptor agonistGIP/GLP-1 dual receptor agonist
ManufacturerEli LillyEli Lilly
Brand namesZepboundMounjaro

Approved uses

PropertyZepboundMounjaro
Approved indicationsChronic weight management, Obstructive sleep apnea (adults with obesity)Type 2 diabetes

Dosing

PropertyZepboundMounjaro
Typical dosingTitrate to 15 mg (weekly SC injection)Titrate to 15 mg (weekly SC injection)

Side effects & warnings

PropertyZepboundMounjaro
Top side effectsNausea (29.6%), Diarrhea (23%), Vomiting (12.6%)Nausea (29.6%), Diarrhea (23%), Vomiting (12.6%)
Contraindications——
Boxed warningYesYes

Special populations

PropertyZepboundMounjaro
PregnancyC — Discontinue at least 1 month before a planned pregnancy.C — Discontinue at least 1 month before a planned pregnancy.

Storage

PropertyZepboundMounjaro
StorageRefrigerate before first use. After first use, room temperature up to 21 days.Refrigerate before first use. After first use, room temperature up to 21 days.

Cost

PropertyZepboundMounjaro
Avg monthly cost$1059.87$1023.04

FDA boxed warning

Zepbound: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Mounjaro: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Already on Zepbound and considering Mounjaro?

Same drug, switch when diabetes diagnosis becomes the primary indication.

Read the switching guide

Frequently asked

What is the difference between Zepbound and Mounjaro?

Zepbound is tirzepatide (GIP/GLP-1 dual receptor agonist) and Mounjaro is tirzepatide (GIP/GLP-1 dual receptor agonist). Both contain the same active ingredient, dosed differently for different FDA-approved indications.

Is Zepbound or Mounjaro more effective for weight loss?

Zepbound and Mounjaro share the same active ingredient (tirzepatide). Average weight loss outcomes track the FDA-approved dose for each brand: STEP 1 reported 14.9% mean weight loss on the higher chronic-weight-management dose vs roughly half that on the lower diabetes-dose. The differentiator is dosing and indication, not molecule potency.

Can I switch between Zepbound and Mounjaro?

Yes — see our directional switching guide at /switching/zepbound-to-mounjaro for FDA-label dose conversion and what to expect during the transition.

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