What are the most common side effects of Ozempic?

The most commonly reported side effects of Ozempic from trial data are nausea, vomiting, diarrhea, constipation, headache.

How long do Ozempic side effects last?

Most Ozempic side effects (especially gastrointestinal) are dose-related and typically subside within 2-4 weeks at each dose level. Side effects are most pronounced during titration.

Trial-sourced incidence data

Ozempic side effects

Ozempic (semaglutide) has 5 documented side effects from peer-reviewed Phase 3 trial data. Click any effect for a patient-facing deep dive with management guidance.

Nausea
moderate20.3% of trial patientsgastrointestinal
Vomiting
moderate9.2% of trial patientsgastrointestinal
Diarrhea
moderate8.5% of trial patientsgastrointestinal
Constipation
mild6.5% of trial patientsgastrointestinal

Incidence rates from peer-reviewed pivotal-trial publications and FDA prescribing information. Individual experience varies — discuss any new symptoms with your prescriber. Medically reviewed by Jane Novak, MD, MPH.