Ozempic side effect
Vomiting is less common than nausea — about 10–15% of GLP-1 users experience it, usually in the first month of titration. Persistent vomiting is a reason to call your prescriber.
In trial — Ozempic
24.8%
In trial — placebo
6.6%
Severity
moderate
Source: STEP-1 (Wilding et al., NEJM 2021)
Same mechanism as nausea — slowed gastric emptying plus enhanced fullness signaling. Vomiting tends to follow a high-fat or large meal during the peak-nausea window.
Timeline
Most episodes happen within 48–72 hours of a dose increase. Tapers within 1–2 weeks at a stable dose.
Call your prescriber if:
Often, yes. Most prescribers will either pause titration or step the dose back down one level until your gut adapts. Discontinuing the medication outright is usually unnecessary unless vomiting is severe and persistent.
This is general drug information, not medical advice. Talk to a licensed clinician before changing your dose, stopping, or starting any over-the-counter remedy.
Drug-specific guides for the other commonly reported reactions on Ozempic.
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