Zepbound reference
How to store Zepbound
Refrigerate at 36–46°F. Lilly Direct vials can sit at room temperature up to 21 days after first puncture.
Detailed guidance
- Refrigerate unopened pens and vials at 36–46°F (2–8°C). Never freeze.
- Lilly Direct multi-dose vials: stable at ≤86°F (30°C) for 21 days after first puncture.
- Pre-filled auto-injector pens are single-dose — discard after each use.
Source: Zepbound FDA prescribing information (opens in a new tab)
People also ask
Common questions readers ask
- Can you drink alcohol on Wegovy?
- No hard contraindication, but alcohol tolerance often drops sharply on GLP-1. Many patients also report reduced desire for alcohol — likely a secondary effect of GLP-1 on the brain reward system. Full evidence-graded answer
- Does GLP-1 affect oral birth control?
- Tirzepatide (Mounjaro, Zepbound) has documented reduced absorption of oral contraceptives during the first 4 weeks of each dose increase. Use backup contraception for ~4 weeks after starting + after each step-up. Semaglutide has no documented effect. Full evidence-graded answer
- Can I take GLP-1 while pregnant?
- No. All FDA-approved GLP-1s carry a pregnancy contraindication. Stop GLP-1 at least 2 months before planned conception due to its long half-life. Full evidence-graded answer
- Is it safe to take GLP-1 long-term?
- Liraglutide has 15+ years of post-marketing data (Victoza approved 2010). Semaglutide has 8+ years (Ozempic approved 2017). No new class-wide safety signals have emerged in extended follow-up. Chronic use is the FDA-approved indication for both T2D and obesity. Full evidence-graded answer
- Do I need to exercise on Wegovy?
- Yes — resistance training specifically. Without it, 25-40% of weight lost on GLP-1 comes from lean muscle. Cardio is a bonus; resistance is the non-negotiable. Full evidence-graded answer
Next step
See the full Zepbound drug profile — efficacy, side effects, cost, and provider options.
See full Zepbound profileEditorial information based on FDA prescribing data. Not personal medical advice. For urgent symptoms call your prescriber or 911.