Evidence-graded answer
Do GLP-1 medications affect mood or depression?
Mixed evidence. The FDA label has a precaution but no boxed warning. Some patients report improved mood (likely from weight loss + glycemic control); a smaller subset reports increased anxiety or low mood, especially in early weeks. Pre-existing depression history is a flag for closer monitoring.
The 2024 FDA review of suicidal ideation in GLP-1 reports found no causal link in the aggregated trial data.
If you have a history of depression or active suicidal thoughts, talk to your prescriber before starting — most clinicians screen using PHQ-9 at baseline + check-ins.
Stop the drug and seek urgent help for new or worsening depression, mood changes, or thoughts of self-harm.
Source: FDA review on suicidal ideation in GLP-1, fda.gov