Medication comparison
Wegovy vs Wegovy HD
Wegovy and Wegovy HD are both GLP-1 receptor agonist medications used for Chronic weight management and Chronic weight management (BMI >=30, or >=27 with at least one weight-related comorbidity). The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.
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This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.
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Drug A
Wegovy
semaglutide
GLP-1 receptor agonist
Novo Nordisk
See full overviewDrug B
Wegovy HD
semaglutide 7.2 mg
GLP-1 receptor agonist
Novo Nordisk
See full overviewOverview
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Generic name | semaglutide | semaglutide 7.2 mg |
| Drug class | GLP-1 receptor agonist | GLP-1 receptor agonist |
| Manufacturer | Novo Nordisk | Novo Nordisk |
| Brand names | Wegovy | Wegovy HD |
Approved uses
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Approved indications | Chronic weight management | Chronic weight management (BMI >=30, or >=27 with at least one weight-related comorbidity) |
Dosing
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Typical dosing | Titrate to 2.4 mg (weekly SC injection) | Titrate to 7.2 mg (weekly SC injection) |
Side effects & warnings
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Top side effects | Nausea (44.2%), Diarrhea (31.5%), Vomiting (24.8%) | Nausea (common), Vomiting (common), Diarrhea (common) |
| Contraindications | — | Personal or family history of medullary thyroid carcinoma (MTC); Multiple endocrine neoplasia syndrome type 2 (MEN 2); Hypersensitivity to semaglutide or any product component |
| Boxed warning | Yes | Yes |
Special populations
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Pregnancy | C — Discontinue at least 2 months before a planned pregnancy. | Discontinue >=2 months before planned pregnancy |
Storage
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Storage | Refrigerate before first use. After first use, room temperature up to 28 days. | Refrigerate 2-8 C unopened. After first use: room temp up to 28 days. |
Cost
| Property | Wegovy | Wegovy HD |
|---|---|---|
| Avg monthly cost | $1349.02 | $1349.00 |
FDA boxed warning
Wegovy: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Wegovy HD: Not established in humans, rodent C-cell tumor signal only; human relevance unknown per FDA label. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or MEN 2.
Frequently asked
What is the difference between Wegovy and Wegovy HD?
Wegovy is semaglutide (GLP-1 receptor agonist) and Wegovy HD is semaglutide 7.2 mg (GLP-1 receptor agonist). They have different active ingredients and slightly different side-effect profiles.
Is Wegovy or Wegovy HD more effective for weight loss?
See each drug's clinical-trials section for the registrational outcome data (SURMOUNT for tirzepatide; STEP for semaglutide; SCALE for liraglutide). Average weight loss varies by trial duration, dose ceiling, and adherence.
Can I switch between Wegovy and Wegovy HD?
Switching between GLP-1 medications requires re-titration when crossing active ingredients (semaglutide ↔ tirzepatide). Always coordinate with your prescriber before switching.
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