The proportion of a drug that reaches systemic circulation in active form. Injectable GLP-1s (Wegovy, Mounjaro) have higher bioavailability than oral semaglutide (Rybelsus).
A screening calculation of body weight relative to height (kg/m²). FDA-approved weight-management GLP-1s require BMI ≥30, or ≥27 with a weight-related comorbidity.