A second medical condition occurring with the primary one. Hypertension, type 2 diabetes, dyslipidemia, and obstructive sleep apnea are common weight-related comorbidities that lower the BMI threshold for GLP-1 eligibility to 27.
A medication custom-prepared by a licensed compounding pharmacy, often using the same active ingredient as a brand-name drug. The FDA allowed compounded semaglutide during the 2022-2025 shortage; access has tightened since.
A specific situation in which a drug should not be used. GLP-1 contraindications include personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).