What are the most common side effects of Zepbound?

The most commonly reported side effects of Zepbound from trial data are nausea, diarrhea, vomiting, constipation, fatigue.

How long do Zepbound side effects last?

Most Zepbound side effects (especially gastrointestinal) are dose-related and typically subside within 2-4 weeks at each dose level. Side effects are most pronounced during titration.

Trial-sourced incidence data

Zepbound side effects

Zepbound (tirzepatide) has 5 documented side effects from peer-reviewed Phase 3 trial data. Click any effect for a patient-facing deep dive with management guidance.

Nausea
moderate29.6% of trial patientsgastrointestinal
Diarrhea
moderate23% of trial patientsgastrointestinal
Vomiting
moderate12.6% of trial patientsgastrointestinal
Constipation
mild11.7% of trial patientsgastrointestinal

Incidence rates from peer-reviewed pivotal-trial publications and FDA prescribing information. Individual experience varies — discuss any new symptoms with your prescriber. Medically reviewed by Jane Novak, MD, MPH.