Medication comparison
Wegovy HD vs Zepbound
Medically reviewed by Dr. Jane Novak, MD, MPH 8 min read Fact checked Editorial integrityUpdated Jun 5, 2026
Wegovy HD and Zepbound are both prescription medications (GLP-1 receptor agonist vs GIP/GLP-1 dual receptor agonist) used for Chronic weight management (BMI >=30, or >=27 with at least one weight-related comorbidity) and Chronic weight management. The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.