Medication comparison
Zepbound vs Wegovy HD
Zepbound and Wegovy HD are both prescription medications (GIP/GLP-1 dual receptor agonist vs GLP-1 receptor agonist) used for Chronic weight management and Chronic weight management (BMI >=30, or >=27 with at least one weight-related comorbidity). The table below compares FDA-approved indications, dosing, weight-loss outcomes, side effects, contraindications, and current pricing — all sourced from the manufacturer prescribing information.
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This is general drug information, not medical advice. Talk to a licensed clinician before starting, stopping, or switching medication.
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Drug A
Zepbound
tirzepatide
GIP/GLP-1 dual receptor agonist
Eli Lilly
See full overviewDrug B
Wegovy HD
semaglutide 7.2 mg
GLP-1 receptor agonist
Novo Nordisk
See full overviewOverview
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Generic name | tirzepatide | semaglutide 7.2 mg |
| Drug class | GIP/GLP-1 dual receptor agonist | GLP-1 receptor agonist |
| Manufacturer | Eli Lilly | Novo Nordisk |
| Brand names | Zepbound | Wegovy HD |
Approved uses
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Approved indications | Chronic weight management, Obstructive sleep apnea (adults with obesity) | Chronic weight management (BMI >=30, or >=27 with at least one weight-related comorbidity) |
Dosing
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Typical dosing | Titrate to 15 mg (weekly SC injection) | Titrate to 7.2 mg (weekly SC injection) |
Side effects & warnings
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Top side effects | Nausea (29.6%), Diarrhea (23%), Vomiting (12.6%) | Nausea (common), Vomiting (common), Diarrhea (common) |
| Contraindications | — | Personal or family history of medullary thyroid carcinoma (MTC); Multiple endocrine neoplasia syndrome type 2 (MEN 2); Hypersensitivity to semaglutide or any product component |
| Boxed warning | Yes | Yes |
Special populations
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Pregnancy | C — Discontinue at least 1 month before a planned pregnancy. | Discontinue >=2 months before planned pregnancy |
Storage
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Storage | Refrigerate before first use. After first use, room temperature up to 21 days. | Refrigerate 2-8 C unopened. After first use: room temp up to 28 days. |
Cost
| Property | Zepbound | Wegovy HD |
|---|---|---|
| Avg monthly cost | $1059.87 | $1349.00 |
FDA boxed warning
Zepbound: Risk of thyroid C-cell tumors. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Wegovy HD: Not established in humans, rodent C-cell tumor signal only; human relevance unknown per FDA label. Contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or MEN 2.
Frequently asked
What is the difference between Zepbound and Wegovy HD?
Zepbound is tirzepatide (GIP/GLP-1 dual receptor agonist) and Wegovy HD is semaglutide 7.2 mg (GLP-1 receptor agonist). They have different active ingredients and slightly different side-effect profiles.
Is Zepbound or Wegovy HD more effective for weight loss?
Head-to-head trial data favors tirzepatide-based medications (Mounjaro, Zepbound) over semaglutide-based medications (Ozempic, Wegovy) in average percent weight loss. SURMOUNT-1 reported ~20.9% mean weight loss on tirzepatide 15 mg; STEP 1 reported ~14.9% on semaglutide 2.4 mg over comparable timelines.
Can I switch between Zepbound and Wegovy HD?
Switching between GLP-1 medications requires re-titration when crossing active ingredients (semaglutide ↔ tirzepatide). Always coordinate with your prescriber before switching.
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Overview
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